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KMID : 0378019750180020178
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New Medical Journal
1975 Volume.18 No. 2 p.178 ~ p.182
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Experimental Study of Spinal Cord Injury in the Cat
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Abstract
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This experimental study demonstrates the sequence of pathologic changes occurring from hours to days after the spinal cord of a cat had been impacted by a 400 gm cm force. Spinal cord injuries was produced by dropping a 20 gm weight 20 cm height through a vented guide tube to strike the impounder which is placed on the exposed surface of the cord. The surface area of the impounder was 5mmX9mm.
Animals were sacrificed hours or days after injury. The thoracic cord was removed. The specimens were taken for histological study and this was correlated with the clinical observation by Tarlov´s classification.
In the acute group (from an hour to 8 hours after injury), multiple hemorrhages and necrosis occurred in the central gray matter and periaxonal swelling in the white matter adjacent to the gray matter. At I5 days the gray matter was almost entirely replaced by a large central cavity in which numerous lipid phagocytes were accumulated and disuruption of the white matter was remarkable around the central cavity. The motor neurons showed complete central chromatolysis in all animals.
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